BIOL 376Cellular Neurophysiology
- Units
- 0.50
- Faculty
- Science
- Subject
- Biology
When it runs
- F24
- W25
- S25
- F25
- W26
- S26
- F26
- W27
- S27
Ran in 3 of the last 7 terms. Winter 2027: not on the schedule. Spring 2027: schedule not out yet.
This course gives students background in neuronal signaling, ion channels, and methods in electrophysiological recording methods. The course requires completion of neuro-simulation laboratories, which provide an introduction to biophysical modelling to explain the functions of neural systems.
Prerequisites
Antirequisites
None listed.
Leads to
No course lists it as a requisite.
Fall 2026 sections
| Section | Class | Enrolled | Meets |
|---|---|---|---|
| LEC 001 | 7455 | 75 / 75 | MWF 12:30–13:20 |
Reviewed on UW Flow
33% liked it23% easy55% useful
From 15 ratings and 9 comments on UW Flow. The most helpful comments, quoted as written, without names. Read them all on UW Flow.
His teaching is pretty scattered and hard to follow, but once you understand the content is becomes pretty clear and straight forward. You need to understand how the variables influence each other. Once you get that, everything is very simple. Coming from someone who hated and did not understand physics, I can say that taking this course has really helped me understand electricity and electrophysiology. It is difficult to pay attention in lectures since he can be scatter brained, but he is a nice guy and is always willing to help. Do the tutorials, understand how the variables work, and the course is not as horrible as it seems.
Dec 2017 · didn’t like it · 2 found this helpfulOn UW FlowRemove this
This class felt like a physics course it was not what I expected. Also his lecture slides and teaching style were super disorganized and I didn't understand the tutorials. It is interesting, but only take if you are comfortable with physics, specifically electricity and circuits, because it's like the electrophysiology of neurons.
Dec 2022 · didn’t like it · 1 found this helpfulOn UW FlowRemove this
The course itself like others mentioned is incredibly difficult to follow. Multiple spelling and grammar mistakes in the slides and a lot of hours of videos to watch. For me this course wasn't very useful and though the evaluations weren't too hard if you paid attention, you really had to focus on every single thing he said to do well. Would not recommend. Also the prof is awful and really doesn't accommodate students well at all.
Dec 2021 · didn’t like it · 1 found this helpfulOn UW FlowRemove this
The content is really, really cool if you're interested in the cellular functions that go on in the brain. The lab was quite cool, and teaches a lot of the underlying concepts that will be covered. The examination is based on analysis of figures from the textbook - you will want it for this class. Don't buy the courseware if you don't mind filling out a PDF instead of writing on paper. You'll need to, as he says, understand the relationships between the various variables that are manipulated. While not difficult, some people might be turned off by the physics involved in the course.
Jan 2016 · liked it · 1 found this helpfulOn UW FlowRemove this
thought i would enjoy this course. spafford gives you all the info you need for the midterm and exam but its really not presented in an interesting way. either take good notes in class or buy the textbook and learn it yourself. a lot of people end up dropping it cuz its not a physio course, more like applied physics.
Nov 2015 · didn’t like it · 1 found this helpfulOn UW FlowRemove this
Discussed on r/uwaterloo
33 posts and comments in 28 threads mention BIOL 376, July 2015 to December 2024. Quoted word for word, newest first; each reply sits under the post and the comment that started its branch. Search r/uwaterloo for newer posts.
Spring 2024
Biol 476 without 376? Any info on 476 really would be great... 2 points, 4 comments
u/IllustratorHungry880: “I tried to take biol 376 but I am not great with the computer program and dropped it. I really do want to take 476, and I know its generally one large project. Which I am usually good at. Is it doable without 376? What are the topics on? …”
u/hoemaster123: “Neither BIOL 476 or 376 are being offered this year (at least according to quest). However my coworker took 476 (a couple years ago however) without taking 376. …”
Fall 2021
Congratulations on getting through the first week of classes!!!! Tell me something interesting you learned so far in the comments? 💖💕 171 points, 58 comments
u/Epic_Meow: “I learned that neurons occasionally fire on their own, i learned about optogenetics, and i learned that that fall 2019 (when i took orgo 1) was, in fact, 2 years ago (i'm taking orgo 2 this semester)”
u/Epic_Meow: “biol 376”
Spring 2021
Biol 376! 1 point, 0 comments
BIOL 376? 1 point, 0 comments
u/dropofmercury: “taking this class in the fall cause it’s in person, any one taken it before? any advice or an old syllabus I can look at?”
Biol 376 & Biol 428 0 points, 2 comments
u/uecm: “Hope everyone is staying safe in this heat. I've been wondering if anyone took biol 376 and/or biol 428. If you did, how did you find these courses?”
BIOL 376 and CHEM 333 1 point, 0 comments
u/xuevie: “Does anyone have the syllabus for both BIOL 376 and CHEM 333? Older versions are okay, too cuz I wanna see how hard they are. Thanks!”
Fall 2020
Studying for Biol376 5 points, 8 comments
u/Reasonable-Badger-21: “Does anyone have tips for studying for biol376 with Dr. Spafford? The midterm is coming up and I have no idea how to study efficiently for this course”
BIOL 376 Midterm 3 points, 3 comments
u/narwhal_s: “Anyone taken BIOL 376 with David Spafford and can give any insight to past midterms? Are the questions similar to tutorial long answers? Kinda worried for this upcoming midterm. …”
Engelhardt for biol 130 anyone? 0 points, 12 comments
“In this class and the teacher just does not seem great. Out of all my courses she’s flying through everything (unit one test literally tomorrow). …”
u/kirishimeth: “She's not that good in biol 130 but she's great in biol 376, probably because biol 130 is all basic stuff and I've heard she really hates teaching that stuff because it's boring...?”
BIOL 376 0 points, 2 comments
Biol 434 study group 1 point, 3 comments
[deleted]: “Hey, does anyone want to make a biol 434 study group? I'm also in biol 433, biol 376 and biol 342 if anyone is interested in making in a study group.”
Spring 2020
BIOL 376 or BIOL 472 or BIOL 433 WHICH IS THE EASIEST COURSE? 2 points, 3 comments
u/Appropriate_Ad_8991: “Hello everyone! Could anyone tell me which course they found the easiest of out these three? Looking for an easy and low-effort third year science elective. Thank you!”
[deleted]: [deleted]
u/sun-day: “Would you know how it compares to biol 476? I got permission to override biol 376/476 so that I can take biol 487 but have never taken any biol course before”
Check it elsewhere for Fall 2026
- Undergraduate Calendar, 2026–27The official entry
- Requirements for Fall 2026Waterloo’s requisite checker
- Schedule of Classes, Fall 2026Instructors, rooms, live seats
- Quest Class SearchWhere you enrol
- Course outlinesSyllabi from past terms (UW login)
- UW FlowStudent ratings and reviews
- WClassesPast sections back to 2004, and who taught them