PHARM 659Mechanisms of Drug Action

The course will explore mechanisms of drug action including efficacy, toxicity, and related topics such as dosage forms, routes of administration, pharmacokinetics, drug interactions, and pharmacogenetics. Major classes of drugs and drug targets will be explored including G protein-coupled receptors, ion channels, kinases and enzymes, and biologics. This knowledge will be applied to common cardiovascular, pulmonary, endocrine, neurological, and psychiatric disease states, as well as oncology and auto-immune conditions. Methods in preclinical and clinical drug development will be explored using the primary literature.